摘要：

Cooperativity of conformational changes of proteins in frozen solutions leads to the dispersion of reactivity accounted for by the time-dependent rate coefficient k(t) = Bt(alpha-1). The dispersion parameter, 0 < alpha-less-than-or-equal-to 1, increasing with reaction temperature, can be interpreted in terms of activation energy distributions for reaction. In the classical limit, alpha = 1, the activation energy remains constant during the reaction course.

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