General and practical catalytic enantioselective Strecker reaction of ketoimines: significant improvement through catalyst tuning by protic additives
摘要：
Significant improvement in enantioselectivity and catalyst activity was achieved for the catalytic enantioselective Strecker reaction. Using a catalyst (1–2.5 mol %) prepared from Gd(OiPr) and -glucose derived ligand 1, and in the presence of 2,6-dimethylphenol as an additive, high enantioselectivity was obtained from a wide range of ketoimines, including heteroaromatic and cyclic ketoimines. The new method was applied to an efficient catalytic asymmetric synthesis of sorbinil, a therapeutic agent for diabetic complications.Graphic
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DOI：
10.1016/j.tetlet.2004.02.082
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年份：
2004
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来源期刊
Tetrahedron Letters
2004
引用走势
2007
被引量：89
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