SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
摘要：
We describe the identification and characterization of a novel gene, sur-8 , that positively regulates Ras-mediated signal transduction during C. elegans vulval development. Reduction of sur-8 function suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations, while increase of sur-8 dosage enhances an activated ras mutation. sur-8 appears to act downstream of or in parallel to ras but upstream of raf. sur-8 encodes a conserved protein that is composed predominantly of leucine-rich repeats. The SUR-8 protein interacts directly with Ras but not with the Ras(P34G) mutant protein, suggesting that SUR-8 may mediate its effects through Ras binding. A structural and functional SUR-8 homolog in humans specifically binds K-Ras and N-Ras but not H-Ras in vitro.
展开
关键词：
Animals Mammals Vulva Caenorhabditis elegans Adaptor Proteins, Signal Transducing ras Proteins Protein Kinases Proto-Oncogene Proteins c-raf Mitogen-Activated Protein Kinase 1 Caenorhabditis elegans Proteins
DOI：
10.1016/S0092-8674(00)81227-1
被引量：
年份：
1998
Elsevier
(全网免费下载)
Elsevier
万方医学
Semantic Scholar
(全网免费下载)
Semantic Scholar
查看更多
dx.doi.org
Cell Press
NCBI
NCBI
Cell Press
(全网免费下载)
Europe PMC
ResearchGate
EureKaMag.com
(全网免费下载)
EBSCO
pubfacts.com
infona.pl
embor.embopress.org
colorado.edu
bprcem.com
ukpmc.ac.uk
mendeley.com
mysciencework.com
molbiolcell.org
core.ac.uk
(全网免费下载)
wormbook.org
jacionline.org
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
Cell Press
(全网免费下载)
EureKaMag.com
(全网免费下载)
core.ac.uk
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
