A review: The obese strain (OS) of chickens: an animal model with spontaneous autoimmune thyroiditis.

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摘要：

Chickens of the Obese strain (OS) of white Leghorns display an hereditary, spontaneous autoimmume thyroiditis (SAT) beginning within the first few weeks of life and characterized by hypothyroidism, severe mononuclear cell infiltration of the thyroid glands, and circulating thyroglobulin autoantibodies. The fact that this disease occurs in an avian species is of great advantage for various immunologic and embryologic studies. In contrast to most experimentally induced autoimmune diseases SAT is B-dependent. This observation led to a new concept for the classification of autoimmune diseases into T- and B-dependent types with intermediate forms. This classification may be relevant to the proper diagnosis and selective immunosuppressive treatment of this group of immunopathologic conditions. Data are presented which favor both a primary thyroid alteration and an aberration of the immunological self-recognition mechanism as factors underlying the development of SAT.

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关键词：

Animals Phagocytes Thyroiditis, Autoimmune Autoimmune Diseases Poultry Diseases Disease Models, Animal Disease Susceptibility Obesity Thyroglobulin Lymphocyte Transfusion