Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.
摘要：
The current results show that one can exploit the normal regulation of receptor synthesis to stimulate the single normal gene in FH heterozygotes to produce an increased number of . This stimulation can be achieved by drugs that inhibit in the liver and by maneuvers that cause depletion. These two therapeutic approaches are most effective when they are combined. It seems reasonable to speculate that such a profound lowering of plasma cholesterol levels will minimize the of in FH heterozygotes. In a broader sense, the success of this regulatory manipulation raises the possibility that other may be treated through manipulation of regulatory signals that control the rates of synthesis of gene products.
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关键词：
Animals Dogs Humans Ileum Liver Naphthalenes Lovastatin Cholesterol Lipoproteins, LDL Receptors, LDL
DOI：
10.1073/pnas.80.13.4124
被引量：
年份：
1983
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