Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances.
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摘要：
With few exceptions, weakly basic compounds that are sufficiently lipophilic in their neutral forms and sufficiently hydrophilic in their protonated forms accumulate in lysosomes. When the concentration within the lysosomes becomes sufficiently high, osmotic swelling occurs. The cells then take on a vacuolated appearance. The concentrations at which different weak bases cause lysosomal vacuolation vary over almost three orders of magnitude. For any particular weak base, it is the concentration of the neutral form that determines the extent of uptake and the degree of vacuolation. Chloroquine is anomalous in that concentrations > 30 μM cause less uptake and less vacuolation than do lower concentrations.
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关键词：
Organoids Lysosomes Vacuoles Macrophages Ascitic Fluid Animals Mice Propranolol Amines Atropine
DOI：
10.1083/jcb.90.3.656
被引量：
年份：
1981
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掌桥科研
万方医学
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