The hospital and home use of a 30-second hand-held blood ketone meter: guidelines for clinical practice.

来自 EBSCO

阅读量:

33

作者:

TM WallaceNM MestonSG GardnerDR Matthews

展开

摘要:

Aims To establish the role of the measurement of β-hydroxybutyrate (β-OHB) in distinguishing simple hyperglycaemia from ketosis, and as an indicator of adequate resolution of ketoacidosis, using an electrochemical blood ketone meter. The aim of the study is to assess the accuracy and precision of the meter and to develop clinical guidelines for the use of the ketone meter at home and in hospital. Patients and methods Twenty patients with poor glycaemic control (mean HbA 1c 10.2%) were recruited from the diabetes clinic and 14 patients admitted with diabetic ketoacidosis (DKA) were recruited from two Accident and Emergency Departments. The blood obtained at each routine fingerprick test for glucose measurement was tested for β-OHB using the ketone meter. Plasma β-OHB concentrations were also measured on admission using a laboratory enzymatic method. Results Paired glucose and β-OHB meter readings ( n = 1099) in clinic patients demonstrated that, in the absence of intercurrent illness, β-OHB levels did not exceed 1 mmol/l, irrespective of glucose readings. In the 14 ketoacidotic patients, the mean plasma β-OHB concentration, measured in the laboratory, on admission was 7.4 mmol/l (range 3.9–12.3 mmol/l). The median half-life of β-OHB was 1.64 h (1st IQR 2.27 h, 3rd IQR 1.34 h). The median time taken, from the initiation of treatment, for β-OHB concentrations to fall to below 1 mmol/l was 8.46 h (range 5–58.33 h). Conclusion Near patient blood ketone testing is a useful adjunct to blood glucose monitoring in distinguishing between ketosis and simple hyperglycaemia. The data suggest that β-OHB levels ≥ 1 mmol/l require further action and levels > 3 mmol/l necessitate medical review. In addition, the rate of fall of β-OHB in DKA can be used as an indicator of the adequacy of treatment. Diabet. Med. 18, 640–645 (2001)

展开

DOI:

10.1046/j.1464-5491.2001.00550.x

被引量:

94

年份:

2010

通过文献互助平台发起求助,成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证,认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献,1~5分钟即可下载全文,部分资源由于网络原因可能需要更长时间,请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

来源期刊

Diabetic Medicine
2010/5/13 0:00:00

引用走势

2014
被引量:19

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用