Diastereoselective Synthesisof trans-2,3-Dihydrothiophenes via MulticomponentReactions of Pivaloylacetonitrile, Aldehyde, Amine, and Thiazolidinedione
摘要：
Polyfunctionalized TRANS-2,3-dihydrothiophenes are efficiently synthesized from the four-component reactions of thiazolidine-2,4-dione, aromatic aldehydes, secondary amines, and pival-oylacetonitrile. The reaction mechanism involves Knoevenagel condensation, Michael addition, and characteristic ring-opening of thiazolidine-2,4-dione followed by an intramolecular ring-closure process
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DOI：
10.1055/s-0030-1258272
被引量：
年份：
2010
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2012
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