Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides.
摘要：
We report the analysis and characterization of natural and modified oligonucleotides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The present technology was highly improved for this class of compounds by using a new matrix, 2,4,6-trihydroxy acetophenone, together with di- and triammonium salts of organic or inorganic acids to suppress peak broadening due to multiple ion adducts. This methodology can be used in combination with time dependent degradation of oligonucleotides by exonucleases as powerful tool to determine sequence compositions.
展开
DOI：
10.1093/nar/21.14.3191
被引量：
年份：
1993
国家科技图书文献中心
(权威机构)
academic.oup.com
Semantic Scholar
(全网免费下载)
Semantic Scholar
万方医学
查看更多
掌桥科研
dx.doi.org
NCBI
Oxford Univ Press
(全网免费下载)
Oxford Univ Press
NCBI
Europe PMC
NCBI
(全网免费下载)
ResearchGate
ProQuest
core.kmi.open.ac.uk
biomedsearch.com
(全网免费下载)
mendeley.com
mysciencework.com
paperity.org
clinchem.org
core.ac.uk
deepdyve.com
onAcademic
pnas.org
Oxford University Press (OUP)
(全网免费下载)
Semantic Scholar
(全网免费下载)
Oxford Univ Press
(全网免费下载)
NCBI
(全网免费下载)
biomedsearch.com
(全网免费下载)
Oxford University Press (OUP)
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
请先登入
相似文献
参考文献
引证文献
辅助模式
0
引用
文献可以批量引用啦~
欢迎点我试用！
