Independent and Additive Effects of Central POMC and Leptin Pathways on Murine Obesity
摘要：
The lethal yellow (A$^Y$/a) mouse has a defect in proopiomelanocortin (POMC) signaling in the brain that leads to obesity, and is resistant to the anorexigenic effects of the hormone leptin. It has been proposed that the weight-reducing effects of leptin are thus transmitted primarily by way of POMC neurons. However, the central effects of defective POMC signaling, and the absence of leptin, on weight gain in double-mutant lethal yellow (A$^Y$/a) leptin-deficient (lep$^{ob}$/lep$^{ob}$) mice were shown to be independent and additive. Furthermore, deletion of the leptin gene restored leptin sensitivity to A$^Y$/a mice. This result implies that in the A$^Y$/a mouse, obesity is independent of leptin action, and resistance to leptin results from desensitization of leptin signaling.
展开
关键词：
Adrenalectomy Alleles Animals Arcuate Nucleus metabolism Blood Glucose analysis Corticosterone blood Crosses Genetic Eating drug effects Energy Metabolism Female Homeostasis Insulin blood Intercellular Signaling Peptides and Proteins Leptin Male Mice Mice Inbred C57BL Mice Obese Neurons metabolism Obesity genetics metabolism Pro-Opiomelanocortin metabolism Proteins genetics metabolism pharmacology Research Support U.S. Gov't P.H.S. Signal Transduction Weight Gain
DOI：
10.1126/science.278.5343.1641
被引量：
年份：
1997
万方医学
doi.org
掌桥科研
Semantic Scholar
dx.doi.org
查看更多
Oxford Univ Press
NCBI
JSTOR
Europe PMC
Cell Press
adsabs.harvard.edu
dialnet.unirioja.es
AGRIS
ResearchGate
EureKaMag.com
(全网免费下载)
ProQuest
EBSCO
joe.endocrinology-journals.org
ganino.com
(全网免费下载)
onacademic.com
diabetes.diabetesjournals.org
jeb.biologists.org
sciencepubs.com
deepdyve.com
highbeam.com
press.endocrine.org
mysciencework.com
scienceopen.com
pharmrev.aspetjournals.org
www.socolar.com
ohsu.pure.elsevier.com
readcube.com
clinmed.rcpjournal.org
sciencemag.org
ajcn.nutrition.org
mendeley.com
go.galegroup.com
ajpendo.physiology.org
fasebj.org
hyper.ahajournals.org
jlr.org
rstb.royalsocietypublishing.org
EureKaMag.com
(全网免费下载)
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
