Chemical approaches to the discovery and development of cancer therapies
摘要：
The chemical sciences are essential for the process of anticancer-drug discovery, and a range of chemical research techniques is needed to develop clinically effective drugs. Improved understanding of the cellular, molecular and genetic basis of cancer has increased the number of drug targets available. What chemical approaches are used to develop agents that target specific features of cancer cells and make these therapeutics more effective? We outline the roles that chemical synthesis and understanding of drug uptake have had in drug discovery over the past 100 years, as well as the chemical insights derived from knowledge of the three-dimensional structure of targets.
展开
DOI：
10.1038/nrc1587
被引量：
年份：
2005
Nature
(全网免费下载)
Springer
Nature
国家科技图书文献中心
(权威机构)
EBSCO
查看更多
掌桥科研
万方医学
dx.doi.org
Europe PMC
NCBI
NCBI
ResearchGate
ProQuest
EBSCO
EBSCO
ftp.palgrave-journals.com
mendeley.com
www.socolar.com
go.galegroup.com
eprints.ucl.ac.uk
kclpure.kcl.ac.uk
mysciencework.com
mct.aacrjournals.org
eprints.pharmacy.ac.uk
onAcademic
Nature
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
