3 '-processing of yeast tRNA(Trp) precedes 5 '-processing
摘要:
Previous analyses of eukaryotic pre-tRNAs processing have reported that 5'-cleavage by RNase P precedes 3'-maturation. Here we report that in contrast to all other yeast tRNAs analyzed to date, tRNA(Trp) undergoes 3'-maturation prior to 5'-cleavage. Despite its unusual processing pathway, pre-tRNA(TrP) resembles other pre-tRNAs, showing dependence on the essential Lsm proteins for normal processing and efficient association with the yeast La homolog, Lhp1p. tRNA T,p is also unusual in not requiring Lhp1p for 3' processing and stability. However, other Lhp1p-independent tRNAs, tRNA(2)(Lys) and tRNA(1)(Ile) follow the normal pathway of 5'-processing prior to 3-processing. [References: 47]
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关键词:
RNA Processing, Post-Transcriptional RNA, Transfer, Trp Saccharomyces cerevisiae RNA加工, 转录后 RNA, 转移, 色氨酸 酵母菌, 酿酒
DOI:
10.1261/rna.2145103
被引量:
年份:
2003



































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