A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
摘要:
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.
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关键词:
Animals Mice, Inbred AKR Mice, Inbred C57BL Mice Mice, Mutant Strains Adenoma Intestinal Neoplasms Anemia Ethylnitrosourea Mutation
DOI:
10.1126/science.247.4940.322
被引量:
年份:
1990













































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