Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support

Methods, compositions, and devices for synthesis of therapeutically useful compounds. The invention provides a rapid approach for combinatorial synthesis and screening of libraries of derivatives of therapeutically important classes of c...

JA Ellman - US

ChemInform Abstract: Oxidative Coupling of Arylglycine-Containing Peptides. A Biomimetic Approach to the Synthesis of the Macrocyclic Actinoidinic-Containi...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a Chem...

D.，A.，EVANS，... - 《Cheminform》

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions

Wang resin-supported Evans' chiral auxiliary ( 23) was designed based on a novel polymer-anchoring strategy, which utilizes the 5-position of the oxazolidi...

T Kotake，Y Hayashi，S Rajesh，... - 《Tetrahedron》

A new efficient synthesis of both enantiomers of macrosphelide core: A potential precursor for functionalized macrosphelides

The asymmetric synthesis of a macrosphelide core (1) and its enantiomer was achieved from (S)- or (R)-3-hydroxybutyrate in excellent yields. These compound...

MATSUYA，Yuji，KAWAGUCHI，... - 《Heterocycles》

偶氮基碳正离子在三环型三唑并杂卓类衍生物合成中的应用研究

苯并二氮杂卓类化合物有显著的中枢神经系统(CNS)活性,目前,人们对这类化合物的合成与活性已有了深入的研究,研究表明当卓环上再并合一个五员杂环后,其代谢稳定性和活性...

孟青青 - 复旦大学

3'-(Arylmethyl)- and 3'-(Aryloxy)-3-phenyl-4-hydroxyquinolin- 2(1H)-ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor

苯并二氮杂卓类化合物有显著的中枢神经系统(CNS)活性,目前,人们对这类化合物的合成与活性已有了深入的研究,研究表明当卓环上再并合一个五员杂环后,其代谢稳定性和活性...

JJ Kulagowski，R Baker，NR Curtis，... - 《Journal of Medicinal Chemistry》

Crystal structure of ((1R)-1,2-((4S)-4-benzyl-2-oxo-oxazolidine-3-yl)- (1S)-1-methyl-2-oxo-ethoxy]-tert-butyl-amino-2,2-dimethyl-propyl)- phosphonic acid d...

C26H43N2O7P, monoclinic, P12(1)1 (No. 4), a = 8.311(2) Angstrom, b = 10.888(2) Angstrom, c = 15.665(3) Angstrom, beta = 97.09(3)degrees, V = 1406.7 Angstro...

C Leroi，MA Ciufolini，M Perrin，... - Zeitschrift für Kristallographie - New Crystal Structures

Oxazolidin-2-Ones: Antibacterial Activity and Chemistry

Since the introduction in the pharmaceutical market of linezolid, an oxazolidin-2-one based new class of antibacterial agents with a unique mechanism of action, this cyclic carbamate bought a wider popularity and interest for the scienti...

G Zappia，C Ingallina，F Ghirga，... - Springer Berlin Heidelberg

Vicarious Nucleophilic Aromatic Substitution via Trapping of an .alpha.-Ketosulfonium Ion Generated by Pummerer-Type Rearrangement of 2-(Phenylsulfinyl)phenols: Preparation of Biaryls

Since the introduction in the pharmaceutical market of linezolid, an oxazolidin-2-one based new class of antibacterial agents with a unique mechanism of action, this cyclic carbamate bought a wider popularity and interest for the scienti...

ME Jung，C Kim，VDB Linda - 《Journal of Organic Chemistry》

Synthesis of Diaryl Ethers, Diaryl Thioethers, and Diarylamines Mediated by Potassium Fluoride-Alumina and 18-Crown-6: Expansion of Scope and Utility(1).

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a Chem...

JS Sawyer，EA Schmittling，JA Palkowitz - 《Journal of Organic Chemistry》