New derivatives of 2,4,6-triiodo-isophthalic acid, proceses for their synthesis and X-ray contrasting materials containing these

阅读量:

10

申请(专利)号:

06/173765

申请日期:

07/30/1980

公开/公告号:

US4348377

公开/公告日期:

09/07/1982

申请(专利权)人:

Bracco Industria Chimica S.p.A. (Milan, IT)

发明人:

E FelderD Pitre

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被引量:

91

摘要:

Novel, radio-opaque compounds comprising water-soluble bis-[N-{3,5-bis-(hydroxyalkylaminocarbonyl)-2,4,6-triiodo-phenyl}-N-(.alph a.-hydroxyacyl)-amino]-alkanes are disclosed for use as X-ray contrast agents. These compounds are relatively simple to synthesize, possess low toxicity and have good stability as well as resistance to hydrolysis. Methods for preparation and use of the compounds are also disclosed.

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