Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
摘要：
The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation-specific epitopes on apoptotic cells, and are deposited in atherosclerotic lesions. The Abs were found to be structurally and functionally identical to classic "natural" T15 anti-PC Abs that are of B-1 cell origin and are reported to provide optimal protection from virulent pneumococcal infection. These findings suggest that there has been natural selection for B-1 cells secreting oxidation-specific/T15 antibodies, both for their role in natural immune defense and for housekeeping roles against oxidation-dependent neodeterminants in health and disease.
展开
关键词：
Animals Mice, Knockout Mice B-Lymphocytes Arteriosclerosis Phospholipid Ethers Immunoglobulin M DNA Primers Apolipoproteins E Lipoproteins, LDL
DOI：
10.1172/JCI8472
被引量：
年份：
2000
BMJ
掌桥科研
万方医学
dx.doi.org
Pubmed Central
(全网免费下载)
查看更多
Europe PMC
NCBI
NCBI
(全网免费下载)
Cell Press
Oxford Univ Press
NCBI
JBC
ResearchGate
ResearchGate
(全网免费下载)
ProQuest
EBSCO
diabetes.diabetesjournals.org
mysciencework.com
学术范
static.jci.org
(全网免费下载)
jimmunol.org
dm5migu4zj3pb.cloudfront.net
(全网免费下载)
ajpheart.physiology.org
jem.rupress.org
bloodjournal.org
bvsalud.org
SAGE
cvi.asm.org
d.scholar.cnki.net
jci.org
core.kmi.open.ac.uk
elifesciences.org
atvb.ahajournals.org
core.ac.uk
readcube.com
molbiolcell.org
content-assets.jci.org
(全网免费下载)
jlr.org
rstb.royalsocietypublishing.org
mendeley.com
fasebj.org
jci.org
(全网免费下载)
学术范
(全网免费下载)
NCBI
(全网免费下载)
Pubmed Central
(全网免费下载)
ResearchGate
(全网免费下载)
content-assets.jci.org
(全网免费下载)
dm5migu4zj3pb.cloudfront.net
(全网免费下载)
jci.org
(全网免费下载)
static.jci.org
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
