Methods and compositions for preventing oxidative degradation of proteins
申请(专利)号：
CA20032492143
申请日期：
2003-07-11
公开/公告号：
CA2492143A1
公开/公告日期：
2004-01-22
申请(专利权)人：
MEDAREX, INC.
被引量：
摘要：
Methods and compositions for preventing oxidative damage to proteins, particularly antibodies, are provided. The compositions include a combination of metal chelators, such as DTPA, EGTA, and/or DEF, and can further include one or more free radical scavengers, particularly scavengers of oxygen radicals. Methods for enhancing protein stability using the compositions of the invention are also disclosed.
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