Chemoenzymatic Asymmetric Synthesis of the Macrolide Antibiotic (-)-A26771B

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29

作者:

S ChatterjeeA SharmaS Chattopadhyay

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摘要:

The formal and total syntheses of the macrolide antibiotic ()-A26771B have been developed wherein the stereochemistries at its C-5 and C-15 centres were installed using the lipase-catalyzed acylation of suitable MeCH(OH) and allylic secondary carbinol centres. A lipase-catalyzed chemoselective and hazard-free acrylation protocol, and a ring-closing metathesis reaction were used to construct the macrocyclic skeleton.

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DOI:

10.1039/C4RA05399K

被引量:

1

年份:

2014

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