Chemoenzymatic Asymmetric Synthesis of the Macrolide Antibiotic (-)-A26771B
摘要：
The formal and total syntheses of the macrolide antibiotic ()-A26771B have been developed wherein the stereochemistries at its C-5 and C-15 centres were installed using the lipase-catalyzed acylation of suitable MeCH(OH) and allylic secondary carbinol centres. A lipase-catalyzed chemoselective and hazard-free acrylation protocol, and a ring-closing metathesis reaction were used to construct the macrocyclic skeleton.
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关键词：
sequential one pot reaction beta-cyclodextrin water as a solvent supramolecular catalysis recyclability of catalyst
DOI：
10.1039/C4RA05399K
被引量：
年份：
2014
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