Chemoenzymatic Asymmetric Synthesis of the Macrolide Antibiotic (-)-A26771B
摘要：
The formal and total syntheses of the macrolide antibiotic ()-A26771B have been developed wherein the stereochemistries at its C-5 and C-15 centres were installed using the lipase-catalyzed acylation of suitable MeCH(OH) and allylic secondary carbinol centres. A lipase-catalyzed chemoselective and hazard-free acrylation protocol, and a ring-closing metathesis reaction were used to construct the macrocyclic skeleton.
展开
关键词：
sequential one pot reaction beta-cyclodextrin water as a solvent supramolecular catalysis recyclability of catalyst
DOI：
10.1039/C4RA05399K
被引量：
年份：
2014
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
