Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family
摘要：
Receptor tyrosine kinases and their ligands mediate cell-and interaction in many organ systems, but have not been known to act in this capacity in the mature immune system. We now provide genetic evidence that three closely related receptor tyrosine kinases, Tyro 3, , and , play an essential immunoregulatory role. Mutant that lack these receptors develop a severe accompanied by broad-spectrum autoimmunity. These phenotypes are cell nonautonomous with respect to lymphocytes and result from the hyperactivation of antigen-presenting cells in which the three receptors are normally expressed.
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关键词：
Immune System Animals Mice Lymphoid Tissue Spleen Antigen-Presenting Cells Dendritic Cells Macrophages Autoimmune Diseases Protein S
DOI：
10.1126/science.1061663
被引量：
年份：
2001
Semantic Scholar
掌桥科研
万方医学
Europe PMC
Oxford Univ Press
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