Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

来自 EBSCO

阅读量:

69

作者:

B BinétruyT SmealM Karin

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摘要:

Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.

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DOI:

10.1038/351122a0

被引量:

1522

年份:

1991

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来源期刊

引用走势

1994
被引量:142

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0

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