Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin.
摘要：
The discovery of and its derivatives as has stimulated a very large number of studies which have, virtually uniformly, documented the ability of these molecules to detoxify harmful reactants and reduce molecular damage. These observations have clear clinical implications given that numerous age-related diseases in have an important free radical component. Moreover, a major theory to explain the processes of invokes radicals and their derivatives as causative agents. These conditions, coupled with the loss of as organisms age, suggest that some diseases and some aspects of may be aggravated by the diminished levels in advanced age. Another corollary of this is that the administration of , which has an uncommonly low toxicity profile, could theoretically defer the progression of some diseases and possibly forestall signs of . Certainly, research in the next decade will help to define the role of in age-related diseases and in determining successful . While increasing life span will not necessarily be a goal of these investigative efforts, improving health and the quality of life in the aged should be an aim of this research.
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DOI：
10.1080/10409230903044914
被引量：
年份：
2009
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