Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
摘要：
Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26 days develop CD8^+ T cells with impaired cytotoxic function, decreased expression of the tumor necrosis factor-α and granzyme B genes, and decreased ability to mediate an antitumor response in vivo. T lymphocytes from tumor-bearing mice expressed T cell antigen receptors that contained low amounts of CD3γ and completely lacked CD3zeta, which was replaced by the Fc_ γ-chain. Expression of the tyrosine kinases p56and p59was also reduced. These changes could be the basis of immune defects in tumor-bearing hosts.
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关键词：
T-Lymphocyte Subsets T-Lymphocytes Animals Mice Colonic Neoplasms Calcium Macromolecular Substances Serine Endopeptidases Lymphocyte Specific Protein Tyrosine Kinase p56(lck Tumor Necrosis Factor-alpha
DOI：
10.1126/science.1465616
被引量：
年份：
1992
IEEEXplore
Wiley
万方医学
dx.doi.org
NCBI
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