The total synthesis of dynemicin A leading to development of a fully contained bioreductively...

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阅读量:

15

作者:

ShairD MatthewYoonT Young

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摘要:

Reports on the synthesis of dynemicin A, a member of the enediyne family of antibiotics, as its racemate in 33 steps. Synthetic strategy; Cross-coupling conditions; Interpolation of the ethylene unit; Biological evaluation of enediyne containing quinone imine systems; In vitro cytotoxicity and mitomycin versus various cancer cell lines.

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被引量:

88

年份:

1996

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