NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing
摘要：
When cytotoxic T-lymphocytes (CTLs) kill infected or cancerous cells they secrete cytolytic proteins (perforin and granzymes) into the target cell. These "death factors" are pre-stored in cytolytic granules within the CTL until an increase in the intracellular Ca2+ drives granule exocytosis. However, not all sources of Ca2+ stimulate exocytosis: we have recently demonstrated that it is the cytolytic granules themselves that are the source of the Ca2+ that most efficiently drives their own exocytosis; release of Ca2+ from the granules is only activated by the Ca2+-mobilizing messenger NAADP (nicotinic acid adenine dinucleotide phosphate) that acts upon target two-pore channels (TPCs) present on the granules. That NAADP is a unique stimulus of exocytosis may be of fundamental importance not only to immunology but to cell biology in general.
展开
关键词：
DOI：
10.4161/cib.24175
被引量：
年份：
2013
Elsevier
Elsevier
(全网免费下载)
国家科技图书文献中心
(权威机构)
Wiley
Semantic Scholar
(全网免费下载)
查看更多
掌桥科研
万方医学
Semantic Scholar
dx.doi.org
NCBI
Europe PMC
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
Cell Press
AGRIS
ResearchGate
(全网免费下载)
ResearchGate
core.ac.uk
scienceopen.com
(全网免费下载)
scienceopen.com
mysciencework.com
deepdyve.com
base-search.net
www.socolar.com
mendeley.com
infona.pl
molbiolcell.org
ora.ox.ac.uk
pubfacts.com
emboj.embopress.org
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
scienceopen.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
