Advance in biocatalytic synthesis of statin intermediates
摘要：
Statins are major type of cholesterol-lowing drugs,in which the(3R,5S)-dihydroxy esters are key structure and important intermediates for the function and production of statins.Bearing two chiral carbon atoms,the production of(3R,5S)-dihydroxy esters may be the rate-limiting steps in the statins manufacture.In this paper,the species,mechanisms,structures and synthetic routes of statins were summarized.Several biocatalystic routes for production of(3R,5S)-dihydroxy esters were also reviewed.
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2012
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