Effects of isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl on physiological variables continuously measured by telemetry in Wistar rats
摘要：
BackgroundThis study investigated effects on cardiovascular parameters during anaesthesia with isoflurane (ISO, 2–3 Vol%), ketamine-xylazine (KX, 100 mg•kg<sup>−1</sup> + 5 mg•kg<sup>−1</sup>) or a combination of medetomidine-midazolam-fentanyl (MMF, 0.15 mg•kg<sup>−1</sup> + 2.0 mg•kg<sup>−1</sup> + 0.005 mg•kg<sup>−1</sup>) in rats throughout induction, maintenance and recovery from anaesthesia. Rats were instrumented with a telemetric system for the measurement of systolic, diastolic and mean arterial pressure (SAP, DAP, MAP), pulse pressure (PP), heart rate (HR) and core body temperature (BT). The parameters were continuously measured before, during and after each type of anaesthesia. Forty minutes after induction, ISO delivery was terminated and MMF was antagonized with atipamezole-flumazenil-naloxone (AFN, 0.75 mg•kg<sup>−1</sup> + 0.2 mg•kg<sup>−1</sup> + 0.12 mg•kg<sup>−1</sup>) whereas KX was not antagonized.
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DOI：
10.1186/s12917-014-0198-3
被引量：
年份：
2014
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