Modulation of the immunogenicity of antigenic determinants by their flanking residues
摘要:
Much of the attention on protein antigens and their induction of T-cell responses has focused on the nature of the interactions of their `core' determinants with the major histocompatibility complex (MHC) or the T-cell receptor (TCR). Here, Kamal Moudgil and colleagues instead emphasize the vital role of the amino acid residues that flank the core antigenic determinant on the outcome of the response.
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关键词:
Salmonella typhimurium Amidohydrolases Nicotinamidase Nicotinamide Mononucleotide Substrate Specificity Biological Transport, Active Kinetics Mutation Genes
DOI:
10.1016/S0167-5699(97)01233-4
被引量:
年份:
1998
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