Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases
摘要：
Certain proteases are not merely degradative enzymes but are highly regulated signaling molecules that control critical biological processes via specific limited proteolysis. Caspase proteinases and their central role in apoptotic cell death provide a prime example of this concept. These cysteine proteinases exist as latent zymogens; however, once activated by apoptotic signals, they systematically dismantle and package the cell by cleaving key cellular proteins solely after aspartate residues. Here we review caspase proteinases with an emphasis on their structure, activation, and critical role in the apoptotic mechanism.
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DOI：
10.1074/jbc.274.29.20049
被引量：
年份：
1999
Taylor & Francis
Elsevier
国家科技图书文献中心
(权威机构)
万方医学
dx.doi.org
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