Hydroacridines XIX [1]. 13C NMR Spectra of Several N-Alkyl-tetradecahydroacridines and their Protonated Species: Investigation of the N-Epimeric Equilibria of the N-Alkyl Groups in the Amines and in the Salts
摘要:
(4aα,8aβ,9aβ,10aα)-Tetradecahydro-10-methylacridin, (4aα,8aβ,9aβ,10aα)-10-ethyl-tetradecahydroacridin, (4aα,8aα,9aβ,10aα)-tetradecahydro-10-methylacridine, (4aα,8aα,9aβ,10aα)-10-ethyl-tetradecahydroacridin and their products of protonation with trifluoroacetic acid were studied by 13C NMR spectroscopy. The first two amines give rise to a pair of N-diastereomeric salts, whereas the latter two yield only the salts with equatorial N-alkyl groups. The N-epimeric equilibria of the N-alkyl groups (equatorial-axial) in the salts and in the amines are discussed.
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DOI:
10.1007/PL00010232
被引量:
年份:
1999
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