A Polarized Epithelium Organized by β- and α-Catenin Predates Cadherin and Metazoan Origins
摘要：
A fundamental characteristic of metazoans is the formation of a simple, polarized epithelium. In higher animals, the structural integrity and functional polarization of simple epithelia require a cell-cell adhesion complex that contains a classical cadherin, the Wnt-signaling protein -catenin and the actin-binding protein ±-catenin. We show that the non-metazoan Dictyostelium discoideum forms a polarized epithelium that is essential for multicellular development. Although D. discoideum lacks a cadherin homolog, we identify an ±-catenin ortholog that binds a -catenin-related protein. Both proteins are essential for formation of the epithelium, polarized protein secretion, and proper multicellular morphogenesis. Thus, the organizational principles of metazoan multicellularity may be more ancient than previously recognized, and the role of the catenins in cell polarity predates the evolution of Wnt signaling and classical cadherins.
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关键词：
Clyde estuary pollution total petroleum hydrocarbon polychlorinated biphenyl polyaromatic hydrocarbon Pb-207/206
DOI：
10.1126/science.1199633
被引量：
年份：
2011
国家科技图书文献中心
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Semantic Scholar
万方医学
掌桥科研
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