Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori.

来自 Semantic Scholar

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118

作者：

AC Wotherspoon，TC Diss，L Pan，PG Isaacson，C Doglioni，A Moschini，MD Boni

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摘要：

Certain features of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue (MALT) suggest the tumour is antigen-responsive. Given the close association between gastric MALT lymphoma and Helicobacter pylori , these organisms might be evoking the immunological response, and eradication of H pylori might inhibit the tumour. 6 patients in whom biopsies showed histological and molecular-genetic evidence of low-grade gastric B-cell MALT lymphoma with H pylori infection were treated with antibiotics. In all cases H pylori was eradicated and in 5, repeated biopsies showed no evidence of lymphoma. These results suggest that eradication of H pylori causes regression of low-grade B-cell gastric MALT lymphoma, and that anti- H-pylori treatment should be given for this lymphoma.

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关键词：

Humans Helicobacter pylori Helicobacter Infections Gastritis Lymphoma, B-Cell Anti-Bacterial Agents Adult Aged Lymphoma, Non-Hodgkin Middle Aged