摘要：

Tissue distributions of Leu-2 + cells in the spleen and draining lymphnodes in cases of clinical gastric cancer were investigated, with special reference to suppressor cell function. Significantly higher Concanavalin-A (Con-A) induced suppressor cell activities were evident in spleen cells (SCs), as compared with peripheral blood lymphocytes (PBLs). As for the tissue distribution, the proportion of Leu-2 + (cytotoxic/suppressor) cells within Leu-1 + cells was higher in the spleen than in the lymphnodes without metastasis. On the other hand, in lymphnodes with metastasis, the enhanced spontaneous suppressor cell activity was noted. In addition, the proportion of Leu-2 + cells within Leu-1 + cells was the greatest in the lymphnodes with metastasis, among the lymphoid organs tested. In lymphnodes without metastasis, lower suppressor cell activities were noted, and numerous Leu-3 + (helper/inducer) cells were present, while Leu-2 + cells were less frequent. NK cell activity against K-562 cells was enhanced by elimination of Leu-2 + /OKT-8 + cells with complement-mediated lysis. These results suggest that Leu-2 + cells located in the spleen and lymphnodes with metastasis may predominantly act as suppressor cells and interact with effector cells.

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