A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and Behavior

来自 EBSCO

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阅读量：

125

作者：

FS Vom Saal，PS Cooke，DL Buchanan，P Palanza，KA Thayer，SC Nagel，S Parmigiani，WV Welshons

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摘要：

Two chemicals previously shown to have estrogenic activity, and octylphenol, were examined for their effects on accessory reproductive organs and daily sperm production in male offspring of fed these chemicals during . These chemicals are used in the manufacture of plastics and other products, and have been detected in food and water consumed by and people. From day 11-17 female were fed an average concentration (dissolved in oil) of or octylphenol of 2 ng/g body weight (2 ppb) and 20 ng/g (20 ppb). The 2 ppb dose of is lower than the amount reported to be swallowed during the first hour after application of a plastic dental sealant (up to 931 micrograms; 13.3 ppb in a 70 kg adult). We found that the 2 ng/g dose of permanently increased the size of the preputial glands, but reduced the size of the epididymides; these organs develop from different tissues. At 20 ng/g, significantly decreased efficiency of sperm production (daily sperm production per g testis) by 20% relative to control males. The only significant effect of octylphenol was a reduction in daily sperm production and efficiency of sperm production at the 2 ng/g dose. A new approach to studying physiologically relevant doses of environmental disruptors is discussed, particularly with regard to the of the reproductive organs, the brain, and .

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关键词：

bisphenol A developmental toxicology dose-response octylphenol

DOI：

10.1177/074823379801400115

被引量：

1275

年份：

1998