摘要：

An oral dosage medicinal composition for ruminant animals is provided which is processed in a manner to cause a medically effective amount of drug contained therein to be slowly released to the animal by virtue of distribution of the medicament throughout a dry, essentially water-insoluble, slowly digestible matrix. Even slower but therapeutically effective drug release is unexpectedly experienced in feverish animals. A compressed dosage form for oral administration is prepared by first treating an admixture of originally essentially undenatured native milk solids and the drug with a sufficient quantity of an aldehydic agent to insolubilize the milk protein solids. This treated composition is then preferably granulated and the granules compressed under sufficient pressure to form a densified body which is not only resistant to disintegration for over 24 hours when tumbled in water, but also has a specific gravity at least greater than about 1 to cause the dosage form upon administration to a ruminant animal to have a tendency to sink in the rumino-recticular fluids and become entrapped in the rumino-recticular compartments.

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