摘要：

The article focuses on the functionalization reaction of the Pd-catalyzed ligand-directed C-H bond. It states that advances regarding the reaction are being made both in novel reactions development and mechanistic study. It adds that the design of the asymmetric C-H functionalization remains a critical goal with respect to directing group, substrate, and reagent functionalization. Furthermore, it says that mechanistic investigations for the future development of novel reactions are expected.

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