Mitochondrial permeability transition and oxidative stress
摘要：
Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.
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关键词：
GPx, glutathione peroxidase GSH, glutathione MPT, mitochondrial permeability transition P i, inorganic phosphate ROS, reactive oxygen species TPx, thioredoxin peroxidase TSH, thioredoxin
DOI：
10.1016/S0014-5793(01)02316-X
被引量：
年份：
2001
Elsevier
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