Salmonella redirects phagosomal maturation
摘要：
Following invasion of host cells, Salmonella occupies an intracellular vacuole that superficially resembles a phagosome. However, unlike bona fide phagosomes that undergo a maturation process to become microbicidal phago-lysosomes, Salmonella avoid killing by arresting and diverting the maturation program of the invasion vacuole. As a result of this re-routing, the bacteria generate a protected niche where they survive and replicate.
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关键词：
EEA early endosome-associated protein LAMP lysosomal-associated membrane proteins LBPA lyso- bis phosphatidic acid PI3K phosphatidylinositol 3-kinase PI3P phosphatidylinositol 3-phosphate RILP Rab-interacting lysosomal protein SCV Salmonella -containing vacuole Sifs Salmonella -induced filaments SPI Salmonella pathogenicity islands TTSS type III secretion systems
DOI：
10.1016/j.mib.2003.12.005
被引量：
年份：
2004
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