DNA damage and mutation in human cells exposed to nitric oxide in vitro

Nitric oxide (NO路) is a physiological messenger formed by several cell types. Reaction with O2forms oxides that nitrosate amines at pH values near 7. We n...

T Nguyen，D Brunson，CL Crespi，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Correction: Tobacco carcinogens, their biomarkers and tobacco-induced cancer

The devastating link between tobacco products and human cancers results from a powerful alliance of two factors - nicotine and carcinogens. Without either ...

SS Hecht - 《Nature Reviews Cancer》

Differences in Lung Cancer Risk Between Men and Women: Examination of the Evidence

BACKGROUND: Lung cancer incidence is gradually leveling off in U.S. men but is continuing to rise in U.S. women. This increase in U.S. women exceeds that e...

EA Zang，EL Wynder - 《Jnci Journal of the National Cancer Institute》

DNA adduct formation from tobacco-specific N-nitrosamines

Tobacco-specific N-nitrosamines are a group of carcinogens derived from the tobacco alkaloids. They are likely causative factors for cancers of the lung, e...

SS Hecht - 《Mutat Res》

Nitrates, nitrites and N-nitrosocompounds: a review of the occurrence in food and diet and the toxicological implications.

Data on occurrence of nitrate, nitrite and Nnitrosocompounds in food and drinking water, and on total dietary intakes are reviewed. Metabolic, toxicologica...

Walker，R. - 《Food Additives & Contaminants》

Tobacco, alcohol and the risk of gastric cancer by sub-site and histologic type.

Top of pageMATERIAL AND METHODS RESULTS DISCUSSION Acknowledgements REFERENCES Few studies have provided information on the role of smoking and alcohol in ...

W Ye，AM Ekstr?M，LE Hansson，... - 《International Journal of Cancer》

Quantitation of Urinary Metabolites of a Tobacco-specific Lung Carcinogen after Smoking Cessation

We quantified urinary levels of two metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in people who had stopped smoking: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its ...

SS Hecht，SG Carmella，M Chen，... - 《Cancer Research》

Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor.

GASTROENTEROLOGY 1999;116:78-89

Y Miyazaki，Y Shinomura，S Tsutsui，... - 《Gastroenterology》

A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke.

Environmental tobacco smoke has been classified by the Environmental Protection Agency as a carcinogen causally associated with lung cancer in adults, but ...

SS Hecht，SG Carmella，SE Murphy，... - 《New England Journal of Medicine》

Mutagenesis associated with nitric oxide production in transgenic SJLmice

We recently reported development of an experimental model for the study of nitric oxide (NO·) toxicology in vivo. SJL mice were injected with superantigen...

A Gal，GN Wogan - 《Proceedings of the National Academy of Sciences of the United States of America》