摘要：

Four β2 acceptor drugs-cloprenaline,albuterol,procaterol and clenbuterol have been separated on four brush type acylamide chiral stationary phases(CSPs),Whelk-O1,DNB-PG,DNB-Leucine and SH-1 by high performance liquid chromatography.The factors that effect enantioseparation,such as the stractures of drugs and CSPs,have been investigated,and the chiral recognition mechanism has also been briefly discussed based on the molecular interaction model between the drugs and CSPs.Chiral separation of the drugs except Albuterol on four CSPs has been achieved with the maximum separation factor of 1.58.The result shown that the hydrogen bond between the enantiomers and CSPs was the main interaction in the chiral recognition process,but the π-π electron transfer interaction was still the prerequisite for the selective separation.

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