Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors.

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作者：

MAGI Cancer，E Lévy，P Piedbois，M Buyse，JP Pignon，P Rougier，L Ryan，R Hansen，B Zee，B Weinerman

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摘要：

PURPOSE: (5-FU) continuous infusion is superior to 5-FU bolus in patients with advanced , but the survival difference between the two treatments is small and, therefore, the difference in toxicity profile is crucial in choosing a treatment for individual patients.: We conducted a meta-analysis of all randomized trials that compared 5-FU bolus with 5-FU CI, based on individual data from 1,219 patients, to compare the toxicity of the two schedules of 5-FU administration and to identify predictive factors for toxicity. The toxicities considered were World Health Organization (WHO) grade 3 to 4 anemia, thrombopenia, , , nausea/vomiting, diarrhea, , and .: Hematologic toxicity, mainly , was more frequent with 5-FU bolus than with 5-FU CI (31% and 4%, respectively; P <.0001). was less frequent with 5-FU bolus than with 5-FU CI (13% and 34%, respectively; P <.0001). There was no difference between the two treatment groups in terms of other nonhematologic toxicities. Independent prognostic factors were age, sex, and performance status for nonhematologic toxicities, performance status, and treatment for hematologic toxicities, and age, sex, and treatment for .: Based on a large data set, this study confirmed and quantified the toxicity profile of the two schedules of administration of 5-FU and allowed the identification of clinical predictors of toxicity.

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关键词：

Colorectal Neoplasms Fluorouracil Drug Administration Schedule Hematologic Diseases Infusions, Intravenous Injections, Intravenous Middle Aged Mouth Mucosa Nausea Prognosis