Genetic and cell biological analysis of integrin outside-in signaling
摘要：
Integrins are receptors that recognize and bind to and counter receptors. of activated integrins to their ligands induces a vast number of structural and signaling changes within the cell. Large, multimolecular complexes assemble onto the cytoplasmic tails of activated integrins to engage and organize the , and activate signaling pathways that ultimately lead to changes in gene expression. Additionally, integrin-mediated signaling intersects with growth factor-mediated signaling through various levels of cross-talk. This review discusses recent work that has tremendously broadened our understanding of the complexity of integrin-mediated signaling.
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关键词：
Cytoskeleton Animals Humans Actins Receptor, IGF Type 1 Insulin-Like Growth Factor I Integrins Signal Transduction Gene Expression Regulation Cell Physiological Processes
DOI：
10.1101/gad.1758709
被引量：
国家科技图书文献中心
(权威机构)
Wiley
doi.org
掌桥科研
万方医学
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