Asymmetric aldol reaction organocatalyzed by bifunctional N-prolyl sulfinamides under solvent-free conditions
摘要：
A class of chiral bifunctionalN-prolyl sulfinamide and its TFA salts were prepared and proven to be effective for catalyzing the aldol reaction under solvent-free conditions. In general, the corresponding aldol adducts were obtained with high to excellent yields, and satisfactory diastereo-selectivities and enantioselectivities. A matching effect between chiral proline and sulfinamide moieties was observed in the catalysts. The enantioswitching of both enantiomers in the asymmetric aldol synthesis is found to be dominated by the prolyl moiety.
展开
关键词：
alcohols (benzene compounds diastereoselective syntheses, enantioselective syntheses (incl. cis/trans-isomerism
DOI：
10.1039/c4ra03362k
被引量：
年份：
2014
相似文献
参考文献
引证文献
来源期刊
研究点推荐
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
