Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells.
摘要：
Bombesin and the C-terminal portion of gastrin-releasing peptide (GRP 14–27) each increase clonal growth rate and colony-forming efficiency of normal human bronchial epithelial cells. These effects occur in the presence or absence of an optimal concentration (5 ng/ml) of epidermal growth factor (EGF). In contrast to EGF bombesin and GRP 14–27 do not stimulate cell migration. Thus, bombesin and the C-terminal fragment of gastrin-releasing peptide represent a new class of peptides mitogenic for normal human epithelial cells.
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DOI：
10.1016/0014-4827(84)90466-X
被引量：
年份：
1984
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来源期刊
Experimental Cell Research
7/1984
引用走势
1993
被引量：51
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