A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
摘要：
The genetic change that leads to the activation of the oncogene in T24 human bladder carcinoma cells is shown to be a single point mutation of guanosine into thymidine. This substitution results in the incorporation of valine instead of glycine as the twelfth amino acid residue of the T24 oncogene-encoded p21 protein. Thus, a single amino acid substitution appears to be sufficient to confer transforming properties on the gene product of the T24 human bladder carcinoma oncogene.
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关键词：
Humans Cell Line Neoplasm Proteins Base Sequence Mutation Oncogenes Gene Expression Regulation Amino Acid Sequence Urinary Bladder Neoplasms Retroviridae
DOI：
10.1038/300149a0
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