Regulation of Macrophage Function by Adenosine
摘要：
Following its release into the extracellular space in response to metabolic disturbances, the endogenous nucleoside adenosine exerts a range of immunomodulatory effects and cells of the mononuclear phagocyte system are among its major targets. Adenosine governs mononuclear phagocyte functions via 4 G-protein-coupled cell membrane receptors, which are denoted A(1), A(2A), A(2B), and A(3) receptors. Adenosine promotes osteoclast differentiation via A(1) receptors and alters monocyte to dendritic cell differentiation through A(2B) receptors. Adenosine downregulates classical macrophage activation mainly through A(2A) receptors. In contrast A(2B) receptor activation upregulates alternative macrophage activation. Adenosine promotes angiogenesis, which is mediated by inducing the production of vascular endothelial growth factor by mononuclear phagocytes through A(2A), A(2B), and A(3) receptors. By regulating mononuclear phagocyte function adenosine dictates the course of inflammatory and vascular diseases and cancer.
展开
关键词：
Macrophages Osteoclasts Animals Humans Neoplasms Vascular Diseases Inflammation Receptors, Purinergic P1 Adenosine Signal Transduction
DOI：
10.1161/ATVBAHA.111.226852
被引量：
年份：
2012
国家科技图书文献中心
(权威机构)
Semantic Scholar
doi.org
掌桥科研
dx.doi.org
查看更多
Europe PMC
NCBI
NCBI
Oxford Univ Press
AACR
ResearchGate
ResearchGate
(全网免费下载)
www.socolar.com
学术范
mendeley.com
jleukbio.org
atvb.ahajournals.org
jvi.asm.org
atvbahajournals.doctorsofdiet.com
hungary.pure.elsevier.com
atvb.ahajournals.org
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
