Viral miRNAs exploiting the endosomal-exosomal pathway for intercellular cross-talk and immune evasion
摘要：
Persistent herpesviruses encode several microRNA species to manipulate their host cell in cis and in trans. Viral microRNA utilize host cell processing machinery, which – in part – may involve endosomal sorting. A special endosomal microRNA sorting route may exist. We have shown that viral microRNA are secreted in endosome-derived exosomes to manipulate neighboring cells. Here we discuss new insights in routes for microRNA sorting and secretion using Epstein–Barr virus as model system.
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DOI：
10.1016/j.bbagrm.2011.08.002
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年份：
2011
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