Protein tyrosine phosphatases in signal transduction
摘要：
Protein-tyrosyl phosphorylation, regulated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key cellular control mechanism. Until recently, little was known about PTPs. However, the past two years have witnessed an explosion of information about PTP structure, regulation and function. Crystal structures of several PTPs have provided insights into enzymatic mechanisms and regulation and suggested the design of 'substrate-trapping' mutants. Candidate homophilic and heterophilic ligands for transmembrane PTPs have been identified, and roles for transmembrane PTPs in regulating cell-cell interactions have been suggested. Finally, progress has been made in understanding signaling by Src homology 2 domain containing PTPs and PTPs controlling yeast osmoregulatory pathways.
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关键词：
Animals Humans Receptors, Cell Surface Signal Transduction Protein Conformation src Homology Domains Phosphorylation Protein-Tyrosine Kinases Protein Tyrosine Phosphatases Cytokines
DOI：
10.1007/978-3-642-79215-1_6
被引量：
年份：
1997
Elsevier
Springer
Semantic Scholar
Ingenta
dx.doi.org
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