Down-regulation of cortical β-adrenoceptors by chronic treatment with functional NMDA antagonists
摘要：
Down-regulation of cortical β-adrenoceptors is observed in laboratory animals following chronic treatment with many clinically effective antidepressant therapies. [ 3 H]Dihydroalprenolol (DHA) binding to cortical β-adrenoceptors was examined in mice treated with the functional NMDA antagonists 1-aminocyclopropane-carboxylic acid (ACPC) and MK-801. ACPC and MK-801 reduced [ 3 H]DHA binding by 19 ( P >0.05) and 21% ( P <0.05), respectively, while imipramine produced a 23% ( P <0.05) reduction. No corresponding changes in the K d of [ 3 H]DHA were observed. These findings are consistent with the observation that functional NMDA antagonists are active in animal models commonly used to evaluate antidepressants and may represent a novel approach to the treatment of depression.
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关键词：
β-Adrenoceptor Antidepressant NMDA receptor Imipramine 1-Aminocyclopropanecarboxylic acid MK-801
DOI：
10.1007/BF02801986
被引量：
年份：
1992
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