摘要：

The nuclear laminsreype V intermediateilament proteinshatormeshworksthe innerspectfhe nuclear envelopendrelso presenthroughouthe nuclear interior.hroughheseeshworktructures, laminsegulatehehape,ize,ndechanical propertiesfhe nucleus. Duringhe last 25 years,he Goldman laboratoryastudiedherganizationnd dynamic propertiesfhe lamins inhe nucleus.hesetudiesaveharacterizedheolef lamin phosphorylation in nuclear laminassemblynd disassembly duringitosis.urthermore,urtudiesave demonstratedoleorhe lamins inhromatinodificationnd epigenetics,ranscription,nd DNAeplication.ecently,he discoveryf numerousutations inhe gene encoding-type laminsausingheollectionf diseases knowns laminopathiesas provided new insights intoheolesf lamins inellularegulationnd differentiation.

展开