An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by thiamine hydrochloride in water under ultrasound irradiation
摘要：
An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using thiamine hydrochloride as a catalyst has been achieved. These ultrasound-assisted reactions proceed efficiently in water in the absence of organic solvent. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
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关键词：
Biginelli reaction Dihydropyrimidinones (DHPMs Thiamine hydrochloride Multi-component reactions Ultrasonication
DOI：
10.1016/j.tetlet.2010.04.037
被引量：
年份：
2010
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